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I’ll bet you’re gaining weight.

Paxil and weight gain go together like salt and pepper. The fact that Paxil and other antidepressants make many users gain weight has been known for decades. Unfortunately, the information was slow in trickling down to the doctors who usually prescribe them.

I guess somebody had to be the last to know… Why the professed ignorance? You don’t have to spend much time in a doctor’s waiting room before noticing the almost constant parade of drug reps and various other assorted characters that bombard your physician on a daily basis. Not only do they fight over who gets to bring your doctor lunch, they also serve as the information source regarding the effects of their drugs.

Why You Gain Weight with Paxil Paxil, like the other drugs in its class, can impede specific enzymes in your liver that allow your metabolism to function correctly.

so Paxil and other SSRI’s impede certain neuroendocrine system pathways. The two major hormones that regulate metabolism are insulin and leptin.

Insulin works mostly within each individual cell, while leptin works between cells. Leptin regulates blood sugar through two different pathways. One controls appetite and fat storage, while the other is responsible for telling the liver what to do with its stored glucose. The fat-cell derived hormone leptin may be the key to weight gain, with or without taking Paxil.

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From: (this should help) http://www.join-the-fun.com/paxil-and-weight-gain.html

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